Practice guidelines that may kill

Attributes of clinical guidelines that influence use of guidelines in general practice: observational study.

OBJECTIVE To determine which attributes of clinical practice guidelines influence the use of guidelines in decision making in clinical practice. DESIGN Observational study relating the use of 47 different recommendations from 10 national clinical guidelines to 12 different attributes of clinical guidelines-for example, evidence based, controversial, concrete. SETTING General practice in the...

Single-Cell Analysis: The Differences That Kill

Using single-cell RNA sequencing, Avraham et al. investigate how variability in macrophage response to infection is controlled by variability within the pathogen population. They find that heterogeneous expression of the Salmonella virulence factor PhoP and subsequent cell-wall modifications lead to the bimodal induction of the interferon-response in infected macrophages.

Drugs that Kill Cancer Stem-like Cells

Designing surfaces that kill bacteria on contact.

Poly(4-vinyl-N-alkylpyridinium bromide) was covalently attached to glass slides to create a surface that kills airborne bacteria on contact. The antibacterial properties were assessed by spraying aqueous suspensions of bacterial cells on the surface, followed by air drying and counting the number of cells remaining viable (i.e., capable of growing colonies). Amino glass slides were acylated wit...

Patient Oriented Evidence That Matters: 2017: Important Studies That May Change Your Practice

The amount of information in family medicine can be overwhelming for medical students and residents. Somehow, through this information jungle, learners need to be able to make costeffective recommendations to their patients based on the best available evidence to benefit individual patients and the public health in a system with limited resources. Educators in family medicine have advocated for...